Investigation of phytochemical contents, in vitro antioxidant and antibacterial behavior and in vivo anti-inflammatory potential of Ecballium elaterium methanol fruits extract

Nowadays, increasing in prevalence of multiple drug resistance implies the development of new synthetic antibacterial, antioxidative and anti-inflammatory drugs from alternative sources (Papadoupoulo et al., 2005). Therefore, there is a renewed interest in natural substances containing phytoconstituents that exhibited several biological properties. They are used in health to prevent oxidative deterioration and some chronic diseases (Tel-Çayan et al., 2015). The development of phagocytes and the production of non-free radicals (H2O2) and radicals of O2 and OH species induced many inflammatory disorders which caused many chronic diseases (Zeng et al., 2017). Medicinal plant therapy was well known for their richness in anti-inflammatory substances. In fact, herbal extracts and their major phytochemical compounds possess a good anti-inflammatory potential (Lee et al., 2011).